Monday, December 9, 2013

Organic Acid Test

An Organic Acid Test (OAT) allows you to know what is going on with yeast and bacterial overgrowth in the body, along with other nutritional markers. 

If you click the link above and scroll to page 7, you can read the explanation of her results. In summary, her OAT showed: 
  • high fungal/ yeast markers indicating yeast or fungus overgrowth
  • high 4-hydroxybenzoic acid,  which may be due to bacterial overgrowth of the GI tract, intake of fruits such as blueberries rich in polyphenols (anthocyanins, flavonols, and hydroxycinnamates), or may be from paraben additive exposure.
  • High succinic acid, which may indicate a relative deficiency of riboflavin and/or coenzyme Q10, or of general gut dysbiosis. 
  • High HPHPA, associated with behavioral, GI, and/or neuropsychiatric effects.  GI symptoms may include diarrhea or constipation. HPHPA is an abnormal phenylalanine metabolite produced by Clostridia 
  • High oxalates 
  • Vanylmandelic acid (VMA) below mean 
  • 5-hydroxyindoleacetic acid (5-HIAA) levels below the mean, which may indicate lower production of the neurotransmitter serotonin. 
  • High quinolinic acid / 5-HIAA ratio,  indicates an imbalance of these organic acids and may be a sign of neural excitotoxicity.  
  • High ethylmalonic and suberic acids, which may be due to fatty acid oxidation disorders or carnitine deficiency
  • High methylmalonic acid, seen in vitamin B12 deficiency or in defective absorption or transport of vitamin B12
  • Pyridoxic acid (B6) levels below the mean, which may be associated with less than optimum health conditions (low intake, malabsorption, or dysbiosis).  
  • High glutaric acid, can result from glutaric acidemias, fatty acid oxidation defects, riboflavin deficiency, ingestion of medium-chain triglycerides, metabolic effects of valproic acid (Depakene), and celiac disease. 

See this post for our current plan to address these test results through biomedical intervention.

    Click here for more on the OAT, from Great Plains Laboratory.

    The OAT was a simple urine test Rylie did at home and I then mailed in the special packaging it came with to freeze and protect it. Although it did take several tries for Rylie to have enough urine in the cup. :)  The cost was around $300. The test kit was ordered through my Registered Dietitian. Insurance did not cover the cost of the test. The test was processed through Great Plains Lab.

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